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Updated: Jun 6, 2026
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
[Immunoadsorption in highly sensitized renal transplant recipients]
1Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Zhonghua Yi Xue Za Zhi
|November 25, 2010
Summary
Protein A immunoadsorption (IA) therapy effectively reduces antibody levels in highly sensitized kidney transplant patients. Supplemented with induction therapy, IA significantly lowers rejection rates post-transplantation.
Area of Science:
- Nephrology
- Immunology
- Transplantation Science
Context:
- Kidney transplantation is challenged by high levels of pre-formed antibodies, increasing the risk of acute rejection.
- Highly sensitized recipients often have poor outcomes due to antibody-mediated rejection.
- Protein A immunoadsorption (IA) is an extracorporeal technique to remove immunoglobulins.
Purpose:
- To evaluate the efficacy and safety of protein A immunoadsorption (IA) therapy.
- To assess IA's role in preventing acute rejection in highly sensitized renal transplant recipients.
- To analyze the impact of IA on antibody levels and rejection rates.
Summary:
- Retrospective analysis of 12 highly sensitized renal transplant patients treated with IA.
- Significant reductions observed in panel reactive antibody (PRA) Class I and II, and IgG, IgA, IgM levels post-IA.
- Acute rejection occurred in 5 cases, managed with anti-thymocyte globulin or combined IA; infections were observed.
Impact:
- IA therapy effectively reduces antibody titers in highly sensitized renal transplant candidates.
- IA, when combined with induction therapy, demonstrates potential in preventing and mitigating post-transplant acute rejection.
- This approach may improve outcomes for patients with high immunological risk.
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