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Updated: Jun 6, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Generalized dystrophic epidermolysis bullosa and development of squamous cell carcinoma]
Rikke Børthy Petersen1, Christian T Bonde, Grethe Schmidt
1Afdeling for Plastikkirurgi og Brandsarsbehandling, Rigshospitalet, København, Denmark. Rikkebp55@hotmail.com
Abstract:
Severe generalized dystrophic epidermolysis bullosa is described via a clinical case in an adult male. From the time of birth his skin was characterized by extensive blistering, slowly developing into chronic wounds with the formation of pseudosyndactyly. As he grew older extracutaneous involvement from other organ systems was seen. Specifically, the patient presented with chronic anaemia, growth retardation and ocular findings. At the age of 45, squamous cell carcinomas to the extremities indicate imminent amputation in an attempt to improve survival probability.
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