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Microalbuminuria is associated with high adverse event rate following cardiac surgery

Martin Majlund Mikkelsen1, Niels Holmark Andersen, Thomas Decker Christensen

  • 1Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Brendstrupgaardsvej, 8200 Aarhus N, Denmark. majlund@ki.au.dk

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|November 25, 2010
PubMed
Abstract

Insights

Preoperative microalbuminuria significantly increases the risk of death and stroke after cardiac surgery. This finding improves risk prediction beyond the standard EuroSCORE, aiding in better patient management.

Area of Science:

  • Cardiology
  • Nephrology
  • Surgical Outcomes Research

Background:

  • Preoperative risk stratification is crucial for elective cardiac surgery.
  • Microalbuminuria, a marker of endothelial dysfunction, may indicate increased surgical risk.

Purpose of the Study:

  • To determine if preoperative microalbuminuria predicts adverse outcomes after cardiac surgery.
  • To assess if microalbuminuria adds prognostic value to the EuroSCORE.

Main Methods:

  • Prospective follow-up of 1049 patients undergoing elective cardiac surgery.
  • Preoperative assessment of microalbuminuria using urine albumin/creatinine ratio.
  • Registry-based follow-up for 1 year to track mortality, myocardial infarction, stroke, and severe infections.

Main Results:

  • Microalbuminuria was present in 18.5% of patients.
  • Patients with microalbuminuria had doubled to tripled adjusted risks of all-cause death, stroke, and severe infections.
  • Microalbuminuria improved the predictive accuracy of the EuroSCORE for mortality.

Conclusions:

  • Preoperative microalbuminuria is an independent predictor of adverse long-term outcomes in elective cardiac surgery.
  • Microalbuminuria provides valuable prognostic information beyond the EuroSCORE, enhancing risk assessment for mortality.

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