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Updated: Feb 10, 2026

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
Published on: September 19, 2019
Emerging concepts in the pathophysiology of traumatic brain injury
Brian J Zink1, Joanna Szmydynger-Chodobska, Adam Chodobski
1Department of Emergency Medicine, Alpert Medical School of Brown, University Rhode Island Hospital & The Miriam Hospital, 593 Eddy Street, Claverick 2, Providence, RI 02903, USA. Brian_Zink@Brown.edu
Abstract:
A complex set of molecular and functional reactions is set into motion by traumatic brain injury (TBI). New research that extends beyond pathological effects on neurons suggests a key role for the blood-brain barrier, neurovascular unit, arginine vasopressin, and neuroinflammation in the pathophysiology of TBI. The prevalence of molecular derangements in TBI holds promise for the identification and use of biomarkers to assess severity of injury, determine prognosis, and perhaps direct therapy. Hopefully, improved knowledge of these elements of pathophysiology will provide the mechanistic clues that lead to improved treatment of TBI.
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