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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Dermal targeting of tacrolimus using colloidal carrier systems
Alexandra S B Goebel1, Reinhard H H Neubert, Johannes Wohlrab
1Faculty of Biosciences/Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Saale, Germany.alexandra.goebel@pharmazie.uni-halle.de
International Journal of Pharmaceutics
|November 25, 2010
Summary
Novel colloidal carrier systems (ME) enhance tacrolimus penetration for chronic inflammatory skin diseases. These systems significantly improve drug delivery to deeper skin layers compared to traditional ointments.
Area of Science:
- Dermatology
- Pharmaceutics
- Materials Science
Background:
- Chronic inflammatory skin diseases require effective long-term topical therapies.
- Epicutaneous drug delivery is crucial for treating skin conditions.
- Tacrolimus is an important anti-inflammatory drug for these diseases.
Purpose of the Study:
- To develop and characterize novel colloidal carrier systems (microemulsions, ME) for tacrolimus.
- To evaluate the dermal delivery potential of these ME compared to a standard ointment.
- To assess the penetration enhancement of tacrolimus using ME.
Main Methods:
- Development and physico-chemical characterization of tacrolimus-loaded ME.
- In vitro penetration studies comparing ME with an ointment vehicle.
- Quantification of tacrolimus in skin layers and acceptor compartments.
Main Results:
- All three developed ME formulations showed enhanced tacrolimus penetration compared to the ointment.
- Significantly higher concentrations of tacrolimus were found in deeper skin layers with ME.
- Bioavailability of tacrolimus from ME was significantly higher (up to 20.95%) than from ointment (6.41%) after 1000 min.
Conclusions:
- Colloidal carrier systems (ME) significantly enhance the dermal penetration of tacrolimus.
- These novel ME offer a promising approach for improved topical therapy of inflammatory skin diseases.
- ME facilitate rapid and deep delivery of tacrolimus to the target skin site.
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