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Updated: Jun 6, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
High factor XI, recurrent pregnancy loss, enoxaparin.
Charles J Glueck1, Joel Pranikoff, Naseer Khan
1Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.com
Fertility and Sterility
|November 25, 2010
Summary
Women with recurrent pregnancy loss may have higher factor XI levels. Treatment with enoxaparin in some cases led to successful live births after multiple pregnancy losses.
Area of Science:
- Reproductive Medicine
- Hematology
Background:
- Recurrent pregnancy loss (RPL) affects a significant number of women.
- The role of thrombophilia, including factor XI levels, in RPL is under investigation.
Purpose of the Study:
- To investigate the association between factor XI levels and recurrent pregnancy loss.
- To evaluate the efficacy of enoxaparin treatment in women with RPL and elevated factor XI.
Main Methods:
- Retrospective analysis of factor XI levels in women with and without pregnancy loss.
- Case series of women with RPL and high factor XI treated with enoxaparin.
Main Results:
- A higher proportion of women with RPL had elevated factor XI levels (≥150%) compared to women with no pregnancy loss (16% vs 5%).
- Three women with a history of multiple pregnancy losses and high factor XI received enoxaparin, resulting in 6 term live births and 1 miscarriage over 5 pregnancies.
Conclusions:
- Elevated factor XI levels may be associated with recurrent pregnancy loss.
- Enoxaparin treatment appears promising for improving pregnancy outcomes in selected women with RPL and high factor XI.
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