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Updated: Jun 6, 2026

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

Creativity, innovation and lean sigma: a controversial combination?

Craig Johnstone1, Garry Pairaudeau, Jonas A Pettersson

  • 1CVGI Research Area, Mereside, AstraZeneca R&D Alderley Park, Alderley Edge, SK10 4TG, UK. craig.johnstone@astrazeneca.com

Drug Discovery Today
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Lean Sigma principles can enhance drug discovery and development by fostering innovation. Careful management of standardization, variation, and capacity is key to integrating continuous improvement with research creativity.

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Last Updated: Jun 6, 2026

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

Area of Science:

  • Pharmaceutical Sciences
  • Process Improvement Methodologies

Background:

  • Lean Sigma is increasingly applied in drug discovery and development.
  • Concerns exist that process optimization may stifle creativity and innovation.

Purpose of the Study:

  • To review conditions supporting creativity and innovation in drug discovery.
  • To examine Lean Sigma principles and benefits in this context.
  • To propose a unified approach for innovation and continuous improvement.

Main Methods:

  • Literature review of Lean Sigma principles.
  • Analysis of factors influencing creativity and innovation in research.
  • Examination of potential conflicts between Lean Sigma and research needs.

Main Results:

  • Lean Sigma can be beneficial in drug discovery.
  • Successful integration requires careful management of specific tensions.
  • Three key areas of tension identified: standardization, variation, and capacity utilization.

Conclusions:

  • A unified climate supporting both innovation and continuous improvement is achievable.
  • Addressing the interpretation of standardization, the role of variation, and the use of liberated capacity is crucial.
  • Respecting research needs is paramount for successful implementation.