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Published on: October 11, 2024
Lung transplantation in cystic fibrosis patients in the Czech Republic: initial single-center experience
L V Bartáková1, L Fila, S Adámek
1Department of Pulmonology, 2nd Medical Schoul of Charles University, Prague, Czech Republic.
Background:
Lung transplantation is a well established treatment for advanced lung diseases.
Methods:
We compared the clinical results of patients with cystic fibrosis (CF) entered into the waiting list with those of patients after lung transplantation.
Results:
Among 36 patients with CF on the waiting list, 23 underwent lung transplantation, 8 died, 3 are still on the waiting list, and 2 were excluded from the waiting list. The median waiting list time of 0.48 years (range, 0.03-2.37) was insignificantly longer for patients who died compared with transplanted patients (0.97 vs 0.44 years). Mortality of waiting-list patients was 25.8%. The median survival of transplant patients of 7.48 years (range 0.00-10.85 years) was significantly lower among patients who were colonized (BCC) versus those who were not Burkholderia cepacia complex (0.19 vs 7.48 years; P = .041). The 1-, 3-, and 5-year patient survivals after lung transplantation were 72.9, 54.4, and 54.4, respectively.
Conclusion:
The results of patients with cystic fibrosis on the waiting list versus after lung transplantation in our center were similar to those reported in the literature. We confirmed a less favorable prognosis of BCC-colonized patients.
