Reeling in the catch: advancing cleavable linkers for proteomics
Meng M Rowland1, Michael D Best
1Department of Chemistry, The University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA.
Chemistry & Biology
|November 25, 2010
Abstract:
In global proteomic applications that focus on the characterization of proteins that have been derivatized using bioorthogonal chemistry, a challenge persists in the release of labeled proteins from supports used for purification. In this issue, Yang and coworkers (2010) present a detailed study of the diazobenzene-cleavable linker system as an effective solution for proteomic studies.
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