Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Protein-Protein Interfaces

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Surface Active Agents

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...

Glycocalyx and its Functions

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...

Surface Appendages of Archaea

Surface Appendages of Archaea

Archaeal surface appendages are highly specialized structures essential for environmental adaptation, encompassing roles in adhesion, biofilm formation, and motility. Among these appendages, pili and archaella stand out for their distinct morphologies and functionalities, enabling archaea to thrive in diverse and often extreme environments.Pili: Adhesion and Biofilm FormationPili are filamentous structures assembled from pilin protein subunits, primarily contributing to adhesion and biofilm...

Types of Receptors: Cell Surface Receptors

Types of Receptors: Cell Surface Receptors

Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Conversion of nucleotides sequences into genomic signals.

Journal of cellular and molecular medicine·2002

Same author

[Evaluation of cognitive disorders and screening of delirium in cancer patients receiving morphine. Comparison of the use of the Elementary Test of Concentration, Orientation and Memory (TELECOM)and of the Mini-Mental State Examination (MMSE)].

Presse medicale (Paris, France : 1983)·2001

Same author

A case of veno-occlusive disease complicated by severe hemorrhagic cystitis successfully treated with recombinant plasminogen activator.

Hematology and cell therapy·1997

Same author

Development of listeriosis during vancomycin therapy in a neutropenic patient.

Scandinavian journal of infectious diseases·1996

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

A Method of Targeted Cell Isolation via Glass Surface Functionalization

A Method of Targeted Cell Isolation via Glass Surface Functionalization

Published on: September 20, 2016

Protein surface functional description.

P D Cristea¹, R Tuduce, O Arsene

¹University "Politehnica" of Bucharest, Biomedical Engineering Center, Romania. pcristea@dsp.pub.ro

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|November 25, 2010

Summary

This study introduces a new image-based method to describe nanostructured surfaces, focusing on atom hydrophobicity for protein analysis and nanotechnology applications.

More Related Videos

Protein Engineering by Yeast Surface Display

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

Preparation of Poly(pentafluorophenyl acrylate) Functionalized SiO2 Beads for Protein Purification

Preparation of Poly(pentafluorophenyl acrylate) Functionalized SiO₂ Beads for Protein Purification

Published on: November 19, 2018

Related Experiment Videos

Last Updated: Jun 6, 2026

A Method of Targeted Cell Isolation via Glass Surface Functionalization

A Method of Targeted Cell Isolation via Glass Surface Functionalization

Published on: September 20, 2016

Protein Engineering by Yeast Surface Display

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

Preparation of Poly(pentafluorophenyl acrylate) Functionalized SiO2 Beads for Protein Purification

Preparation of Poly(pentafluorophenyl acrylate) Functionalized SiO₂ Beads for Protein Purification

Published on: November 19, 2018

Area of Science:

Nanotechnology
Computational Biology
Materials Science

Background:

Characterizing atomic neighborhoods on protein surfaces is crucial for understanding molecular interactions.
Existing methods may not fully capture the nuances of surface atom properties like hydrophobicity.

Purpose of the Study:

To develop an image-oriented description for artificial and biological nanostructured surfaces.
To create a database of molecular surfaces for nanotechnology research.
To functionalize the characterization of atom neighborhoods on protein surfaces.

Main Methods:

Replaced actual hydrophobicity distribution with an equivalent hydrophobicity density distribution.
Computed distributions in standardized hexagonal or octagonal patterns around surface atoms.
Utilized an image-oriented approach for surface description.

Main Results:

Established a novel method for quantifying hydrophobicity around surface atoms.
Developed a standardized representation of atom neighborhoods.
Laid groundwork for a comprehensive database of molecular surfaces.

Conclusions:

The proposed image-oriented description provides a robust method for analyzing nanostructured surfaces.
This approach enhances the functional characterization of protein surface atoms, particularly hydrophobicity.
The developed database will support diverse nanotechnology research fields.