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Cell micromanipulation with an active handheld micromanipulator.

Jaime Cuevas Tabares¹, Robert A Maclachlan, Charles A Ettensohn

¹University of Valladolid, Spain.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|November 25, 2010

Summary

This study introduces Micron, an active handheld micromanipulator for precise cell manipulation. Micron enhances accuracy by actively correcting hand movements, improving success rates in delicate biological tasks.

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Area of Science:

Biomedical Engineering
Cell Biology
Robotics

Background:

Micromanipulation of cellular structures requires high precision.
Existing tools often lack intuitive control or sufficient accuracy for delicate tasks.
Handheld tools offer natural dexterity but struggle with microscale precision.

Purpose of the Study:

To introduce and evaluate Micron, an active handheld micromanipulator.
To assess the device's capability for precise manipulation of objects in the tens of microns range.
To demonstrate improved performance in biological tasks compared to unaided manipulation.

Main Methods:

Development of an active handheld micromanipulator (Micron).
Integration of a microscale optical tracker for position sensing.

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Implementation of piezoelectric actuators for active motion error correction.

Benchtop experiments for tip positioning accuracy assessment.

Preliminary trials involving bisection of sea urchin embryos.

Main Results:

Active compensation reduced positioning error by up to 51% compared to unaided performance.
Micron demonstrated intuitive handheld operation for microscale manipulation.
Preliminary experiments showed an increased success rate in sea urchin embryo bisection using Micron.

Conclusions:

The active handheld micromanipulator Micron significantly improves precision in microscale manipulation.
Micron offers a promising tool for delicate biological procedures requiring high dexterity and accuracy.
The device has the potential to enhance success rates in various cell and embryo manipulation applications.