Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Performance Testing and External Validation of an AI Algorithm to Detect and Segment Brain Metastases.

Neuro-oncology·2026
Same author

Mind the gap: challenges and future directions for content-based image retrieval in clinical radiology.

Frontiers in radiology·2026
Same author

Disentangled generative uncertainty-aware multi-modal diffusion segmentation of medical images.

Medical image analysis·2026
Same author

[Training and Experience of Healthcare Professionals in Clinical Teaching: A Study in Primary Care in Chile].

Revista medica de Chile·2026
Same author

The Ischemic Stroke Lesion Segmentation Challenge (ISLES)'24 Dataset: A Multimodal Stroke Imaging Dataset with Hyperacute CT, Acute Postinterventional MRI, and 3-month Clinical Outcomes.

Radiology. Artificial intelligence·2026
Same author

Gastrointestinal Safety of Left Hepatic Lobe Radiation Segmentectomy-Reassuring Data with Room for Further Investigation.

Cardiovascular and interventional radiology·2026

Related Experiment Video

Updated: Jun 6, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Multimodal target correction by local bone registration: a PET/CT evaluation.

Thiago Oliveira-Santos1, Thilo Weitzel, Bernd Klaeser

  • 1Institute for Surgical Technology & Biomechanics, Bern University, Switzerland.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
Summary

This study introduces an improved instrument guidance system (IGS) for PET/CT-guided bone biopsies. The system enhances precision and reduces radiation exposure by minimizing the need for repeated, time-consuming PET/CT scans during interventions.

More Related Videos

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
05:05

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
08:39

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

Related Experiment Videos

Last Updated: Jun 6, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
05:05

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
08:39

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

Area of Science:

  • Medical Imaging
  • Interventional Radiology
  • Oncology

Background:

  • Percutaneous bone biopsies guided by Positron Emission Tomography/Computed Tomography (PET/CT) enable targeting of metabolically active lesions not visible on CT alone.
  • Conventional step-by-step PET/CT guidance is often time-consuming and complex, particularly when lesions lack CT correlation.
  • Minimizing radiation exposure for patients and staff is crucial, necessitating efficient imaging protocols during interventions.

Purpose of the Study:

  • To present a novel multimodal instrument guidance system (IGS) for PET/CT-guided percutaneous interventions.
  • To improve the precision and reduce the duration of bone biopsies, thereby lowering radiation exposure.
  • To enable accurate instrument guidance in dynamic situations with potential patient movement or deformation, using only initial PET/CT and subsequent fast CT scans.

Main Methods:

  • Development and implementation of a multimodal instrument guidance system (IGS) integrated with PET/CT.
  • Utilizing a single, time-efficient combined PET/CT acquisition for initial targeting.
  • Employing fast CT acquisitions for intra-procedural checks and employing the IGS to transfer target coordinates from PET/CT to the current CT view, accounting for patient motion.

Main Results:

  • The IGS streamlines PET/CT-guided interventions, addressing limitations of conventional step-by-step techniques.
  • The system facilitates precise targeting of metabolically active bone lesions even without CT morphological correlation.
  • It enables accurate instrument guidance by compensating for patient movement or deformation between scans, crucial for interventions requiring only initial PET/CT and subsequent CT imaging.

Conclusions:

  • The developed IGS significantly enhances the efficiency and safety of PET/CT-guided percutaneous bone biopsies.
  • This system allows for precise targeting and intervention, even in challenging cases with limited CT visibility and potential patient movement.
  • The approach minimizes the need for repeated time-consuming PET/CT scans, reducing overall radiation exposure during interventions.