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Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...

Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...

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Related Experiment Video

Updated: Jun 6, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

ModBase, a database of annotated comparative protein structure models, and associated resources.

Ursula Pieper¹, Benjamin M Webb, David T Barkan

¹Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA.

Nucleic Acids Research

|November 25, 2010

Summary

This summary is machine-generated.

ModBase is a protein structure model database featuring over 10 million models. It offers automated modeling and prediction tools for enhanced protein structure analysis.

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Area of Science:

Structural Biology
Bioinformatics
Computational Biology

Background:

Protein structure modeling is crucial for understanding protein function.
Databases of reliable protein models aid research and discovery.
Automated pipelines streamline the generation and assessment of protein models.

Purpose of the Study:

To present ModBase, a comprehensive database of annotated comparative protein structure models.
To highlight the capabilities of the ModPipe modeling pipeline and associated resources.
To provide researchers with on-demand modeling and model accuracy prediction tools.

Main Methods:

Utilizing ModPipe, an automated pipeline leveraging Modeller for protein modeling tasks.
Generating comparative models for protein domains.
Implementing quality assessment for predicted protein structures.

Main Results:

ModBase contains over 10.3 million reliable models for 2.4 million unique protein sequences.
The database provides an interface for on-demand model updates and new sequence modeling via ModWeb.
Associated resources like SALIGN, ModEval, PCSS, and FoXS offer advanced analysis capabilities.

Conclusions:

ModBase serves as a valuable resource for protein structure information.
The integrated pipeline and associated servers facilitate comprehensive protein structure analysis.
Accessibility through ModBase and the Protein Model Portal enhances research utility.