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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

Can TNF-α boost regulatory T cells?

Angelina M Bilate1, Juan J Lafaille

  • 1Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, New York, USA.

The Journal of Clinical Investigation
|November 25, 2010
PubMed
Summary

Effector T cells (Teffs) are crucial for maintaining the protective functions of regulatory T cells (Tregs) in preventing autoimmune diseases like type 1 diabetes. This study reveals a previously underappreciated role for Teffs in Treg-mediated immune suppression.

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