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In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
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Vascular disorders in neuro-ophthalmology
1Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA. sohan-hayreh@uiowa.edu
Current Opinion in Neurology
|November 25, 2010
Summary
Systemic corticosteroids significantly improve vision in nonarteritic anterior ischemic optic neuropathy (NA-AION). Thrombolysis is not beneficial and may be harmful for central retinal artery occlusion (CRAO).
Area of Science:
- Ophthalmology
- Neurology
Background:
- Nonarteritic anterior ischemic optic neuropathy (NA-AION) and central retinal artery occlusion (CRAO) are significant causes of vision impairment.
- The optimal management strategies for these conditions remain subjects of ongoing debate.
Purpose of the Study:
- To review the controversial management of NA-AION and CRAO.
- To discuss the efficacy of systemic corticosteroids and aspirin for NA-AION.
- To evaluate the role of thrombolysis in CRAO.
Main Methods:
- Review of recent prospective studies on NA-AION and CRAO management.
- Analysis of treatment outcomes, including visual acuity and visual fields.
Main Results:
- Systemic corticosteroid therapy demonstrated a significantly higher probability of visual acuity and visual field improvement in NA-AION compared to no treatment (P = 0.001 and P = 0.005, respectively).
- Thrombolytic therapy for CRAO showed no beneficial effect and was associated with potential harm, according to recent prospective studies.
Conclusions:
- Systemic corticosteroids represent a promising treatment option for improving outcomes in NA-AION.
- Thrombolysis should be approached with caution in CRAO due to evidence suggesting it may be harmful.
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