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Structural Changes in the Lamina Cribrosa Following Cataract Surgery in Primary Angle-Closure and Primary Open-Angle
Seray Sahin1, Mine Esen Baris1, Suzan Guven1
1Department of Ophthalmology, Ege University Faculty of Medicine, Izmir, Turkey.
Seminars in Ophthalmology
|August 11, 2026
Summary
Cataract surgery altered lamina cribrosa structure in primary angle-closure glaucoma (PACG) but not primary open-angle glaucoma (POAG). These glaucoma structural changes highlight differences in how the lamina cribrosa responds to intraocular pressure reduction between subtypes.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Surgical Outcomes
Background:
- Glaucoma is a leading cause of irreversible blindness.
- The lamina cribrosa (LC) is a critical structure in glaucoma pathogenesis.
- Understanding structural changes post-surgery is vital for managing glaucoma subtypes.
Purpose of the Study:
- To investigate the impact of cataract surgery on specific lamina cribrosa (LC) structural parameters.
- To compare these effects between patients with primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG).
Main Methods:
- Prospective comparative study of 50 eyes (25 PACG, 25 POAG) undergoing cataract surgery.
- Assessment of intraocular pressure (IOP), RNFL thickness, and LC parameters (LCT, LCD, PLD, PLTT) using swept-source OCT pre- and 6 months post-surgery.
- Analysis of changes over time and between groups, adjusted for IOP reduction and age.
Main Results:
- Significant IOP reduction occurred in both PACG and POAG groups post-surgery.
- Cataract surgery led to increased LCT and decreased LCD and PLD in the PACG group.
- No significant LC structural changes were observed in the POAG group post-surgery.
Conclusions:
- Cataract surgery induces measurable lamina cribrosa structural changes in PACG, but not POAG.
- The structural response of the lamina cribrosa to IOP-lowering interventions may differ between glaucoma subtypes.
- Further research is needed to elucidate the mechanisms and clinical significance of these observed differences.
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