Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

Antidepressant Drugs: Overview

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

The Placebo Effect

The Placebo Effect

The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Borderline personality disorder.

Postgraduate medicine·2017

Same author

Dysthymic disorder.

Postgraduate medicine·2017

Same author

Elucidating the association between the self-harm inventory and several borderline personality measures in an inpatient psychiatric sample.

International journal of psychiatry in clinical practice·2017

Same author

Borderline personality disorder and mental health care utilization: The role of self-harm.

Personality disorders·2017

Same author

Research experiences and attitudes among five disciplines of residents in the United States.

Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors·2017

Same author

Criminal Behavior and Borderline Personality: Correlations Among Four Measures.

Innovations in clinical neuroscience·2016

Same journal

Civil commitment in the United States.

Psychiatry (Edgmont (Pa. : Township))·2012

Same journal

Efficacy and Safety of Once- versus Twice-Daily Carbamazepine Extended-Release Capsules for the Treatment of Manic Symptoms in Patients with Bipolar I Disorder.

Psychiatry (Edgmont (Pa. : Township))·2012

Same journal

Management of depression: during pregnancy and the postpartum period.

Psychiatry (Edgmont (Pa. : Township))·2012

Same journal

Neurobehavioral problems associated with phenylketonuria.

Psychiatry (Edgmont (Pa. : Township))·2011

Same journal

Recommendation for DSM-V: A Proposal for Adding Causal Specifiers to Axis I Diagnoses.

Psychiatry (Edgmont (Pa. : Township))·2011

Same journal

The blood brain barrier and the role of ratiometric molecular analysis in schizophrenia.

Psychiatry (Edgmont (Pa. : Township))·2011

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

SSRI-Induced Indifference.

Randy A Sansone¹, Lori A Sansone

¹Dr. R. Sansone is a professor in the Departments of Psychiatry and Internal Medicine at Wright State University School of Medicine in Dayton, Ohio, and Director of Psychiatry Education at Kettering Medical Center in Kettering, Ohio.

Psychiatry (Edgmont (Pa. : Township))

|November 25, 2010

Summary

This summary is machine-generated.

Selective serotonin reuptake inhibitor (SSRI) medications can cause indifference, combining apathy and emotional blunting. This under-recognized syndrome resolves when the SSRI is stopped or changed.

Keywords:

Selective serotonin reuptake inhibitor (SSRI)adverse effects apathy emotional blunting indifference side effects

More Related Videos

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Related Experiment Videos

Last Updated: Jun 6, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Area of Science:

Psychiatry
Pharmacology

Background:

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants.
Existing literature occasionally links SSRI use to behavioral apathy and emotional blunting.

Purpose of the Study:

To propose a unified concept of "SSRI-induced indifference," encompassing apathy and emotional blunting.
To highlight the under-recognized nature and characteristics of this syndrome.

Main Methods:

Literature review and conceptual synthesis.
Analysis of clinical presentation, epidemiology, and treatment.

Main Results:

SSRI-induced indifference may be an under-recognized syndrome with insidious onset.
Symptoms are often dose-dependent and resolve upon drug discontinuation.
Low patient and clinician insight, especially in children and adolescents, contributes to under-recognition.

Conclusions:

SSRI-induced indifference is a potentially common, yet overlooked, side effect.
Treatment may involve dose reduction, augmentation, or switching to non-SSRI antidepressants.