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Fmoc-chemistry of a stable phosphohistidine analogue

Tom E McAllister1, Michael G Nix, Michael E Webb

  • 1School of Chemistry, University of Leeds, Leeds, UK.

Chemical Communications (Cambridge, England)
|November 25, 2010
PubMed

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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...