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Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular
Robert B P Elmes1, Marialuisa Erby, Suzanne M Cloonan
1School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
Chemical Communications (Cambridge, England)
|November 25, 2010
Abstract:
The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
