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Superficial migratory thrombophlebitis and factor XII deficiency
C P Samlaska1, W D James, D L Simel
1Dermatology Service, Walter Reed Army Medical Center, Washington, D.C.
Journal of the American Academy of Dermatology
|May 1, 1990
Summary
A rare case of superficial migratory thrombophlebitis unresponsive to treatment is presented. A factor XII deficiency was identified, suggesting a hypercoagulable state should be considered in similar cases.
Area of Science:
- Vascular Medicine
- Dermatology
Background:
- Superficial thrombophlebitis is an inflammation of superficial veins.
- It can present as painful, erythematous nodules or cords.
Observation:
- A patient presented with a 7-year history of painful, migratory erythematous nodules on extremities, progressing to palpable cords.
- Venograms excluded deep vein thrombosis, and skin biopsies confirmed superficial thrombophlebitis.
- No internal malignancy was detected.
Findings:
- Extensive evaluation revealed a factor XII level of 17% of normal, indicating an underlying hypercoagulable state.
- The patient's condition was recalcitrant to various treatments.
- The unique presentation included chronic superficial migratory thrombophlebitis without deep venous involvement.
Implications:
- This case highlights the importance of considering underlying hypercoagulable states, specifically factor XII deficiency, in patients with recalcitrant superficial migratory thrombophlebitis.
- Further research into the link between factor XII deficiency and superficial thrombophlebitis is warranted.
- This finding may influence diagnostic approaches and treatment strategies for similar conditions.