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Occult lymph node metastasis in laryngeal squamous cell carcinoma: therapeutic and prognostic impact
M Mnejja1, B Hammami, L Bougacha
1Service ORL et chirurgie cervicofaciale, CHU Habib Bourguiba, 3029 Sfax, Tunisia.
Objectives:
To assess the incidence and impact on treatment and prognosis of occult lymph node metastasis in laryngeal cancer.
Patients And Methods:
A retrospective study was performed on 164 patients treated for laryngeal cancer, initially classified as N0, with cervical lymph node dissection.
Results:
Occult metastases were found in 41 neck specimens (12.5%) from 32 patients (19.5%). Involvement per neck level was: 7% level IIa, 2.4% IIb, 4.2% III and 2.7% IV. Lymph node involvement was significantly increased in case of T3T4 tumor or invasion of the pre-epiglottic space or cartilage. Survival was significantly influenced by pN status (pN- = 12 years, vs pN+ = 9 years; P = 0.006).
Conclusion:
Level IIb or IV involvement is rare. Superselective neck dissection (IIa, III) seems to be indicated in T1T2 N0 tumor. In case of advanced tumor or pre-epiglottic space or cartilage invasion, functional neck dissection is mandatory.
