Related Experiment Video
Updated: Jun 6, 2026
08:23
Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages
Published on: May 30, 2019
Bacteremia in Kenyan children presenting with malaria
T Were1, G C Davenport, J B Hittner
1University of New Mexico/Kenya Medical Research Institute, Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kisumu, Kenya.
Journal of Clinical Microbiology
|November 26, 2010
Summary
Bacteremia in children with malaria significantly increases mortality and malnutrition risks, especially when caused by Gram-negative bacteria. This study highlights the need for better diagnostics and treatment in high-transmission areas.
Area of Science:
- Pediatrics
- Infectious Diseases
- Global Health
Background:
- Bacteremia in children with Plasmodium falciparum malaria is understudied, particularly in holoendemic regions.
- Understanding its impact on clinical outcomes is crucial for effective interventions.
Purpose of the Study:
- To investigate the prevalence, etiologies, and clinical outcomes of bacteremia in malaria-infected children in western Kenya.
- To identify risk factors and associations between bacteremia and clinical parameters.
Main Methods:
- Blood cultures and comprehensive clinical, laboratory, hematological, and nutritional data were collected from 585 children (1-36 months) with malaria.
- Multivariate logistic regression was used to analyze associations between bacteremia and various outcomes.
Main Results:
- Bacteremia prevalence was 11.7% (n=506), with nontyphoidal Salmonella spp. as the most common cause.
- Bacteremia was associated with higher mortality (8.5-fold), malnutrition, elevated glucose, and lower hemoglobin levels.
- Gram-negative bacteremia specifically increased risks of respiratory distress, severe malarial anemia, and underweight.
Conclusions:
- Bacteremia is a significant complication in children with P. falciparum malaria, linked to increased malnutrition and mortality.
- Gram-negative bacteremia poses a particularly high risk for severe clinical outcomes.
- Findings underscore the importance of addressing bacteremia in pediatric malaria management.
More Related Videos
09:02An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
Published on: February 17, 2014
05:28Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
Published on: May 12, 2022
Related Concept Videos
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
00:58Symbiosis
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...