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Updated: Jun 6, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Left dorsomedial frontal brain damage is associated with insomnia
Michael Koenigs1, Jessica Holliday, Jeffrey Solomon
1Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA. mrkoenigs@wisc.edu
None:
Insomnia is a common sleep disorder, yet its pathophysiological basis remains poorly understood. Studying a group of 192 patients with focal brain lesions, we show a significant association between insomnia and left dorsomedial prefrontal damage. Our findings are the first to demonstrate a link between insomnia and a discrete locus of brain damage, providing novel insight into the neurobiological mechanisms of sleep maintenance.
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