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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Cutaneous marginal zone lymphomas have distinctive features and include 2 subsets.

James T Edinger¹, Jeffrey A Kant, Steven H Swerdlow

¹Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

The American Journal of Surgical Pathology

|November 26, 2010

Summary

This study suggests two distinct subtypes of cutaneous marginal zone lymphomas (CMZL) based on B-cell heavy chain expression. Findings support CMZL as an indolent B-cell lymphoma with plasmacytic differentiation.

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Area of Science:

Hematology
Oncology
Dermatology

Background:

Cutaneous marginal zone lymphomas (CMZL) classification has varied between WHO/EORTC and subsequent WHO classifications.
Distinctive features of CMZL suggest potential heterogeneity and the existence of two subsets.

Purpose of the Study:

To investigate the clinicopathologic, phenotypic, and genotypic features of 29 CMZL cases with plasmacytic differentiation.
To clarify the classification and potential subsets within CMZL.

Main Methods:

Clinicopathologic assessment of 29 CMZL cases with plasmacytic differentiation.
Immunophenotypic analysis including B-cell heavy chain expression (class-switched vs. IgM).
Evaluation of T-cell populations, follicular dendritic meshworks, and other immune cells.

Main Results:

Two distinct CMZL subsets were identified based on B-cell heavy chain expression: class-switched and IgM.
Class-switched CMZL cases showed T-cell predominance, nodular growth, and lacked CXCR3 B-cell expression.
IgM CMZL cases exhibited B-cell predominance, diffuse CD20+ B-cell proliferation, and had a higher incidence of extracutaneous disease.

Conclusions:

The findings support the existence of two distinct types of cutaneous MALT lymphomas.
Class-switched CMZL cases are highly distinctive, sharing features with extranodal, extramedullary indolent small B-cell lymphomas.
CMZL cases present as CD5-, CD10- indolent small B-cell lymphomas with plasmacytic differentiation and frequent benign follicular structures.