PNAs grafted with (α/γ, R/S)-aminomethylene pendants: regio and stereo specific effects on DNA binding and improved
1Division of Organic Chemistry, National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411008, India.
Chemical Communications (Cambridge, England)
|November 26, 2010
Abstract:
PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (α) or ethylenediamine (γ) segments show regio (α/γ) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with γ(S-am) aeg-PNA being the best in all properties.
