Cutaneous angiosarcoma is a rare aggressive malignant vascular tumour of the skin

Cutaneous angiosarcoma (AS) is a rare aggressive malignant vascular tumour of the skin.

We analysed the cases of cutaneous AS in two large dermatological departments of Saxony during the last 10 years.

A total of eight AS cases were identified, mostly with head and neck involvement. Because of age and late diagnosis, only a minor part was completely resectable. As a palliative therapy pegylated liposomal doxorubicin was used. The drug was well tolerated. Our cases and those published in the literature suggest a high rate of responses and a possible sensitisation to subsequent radiation therapy.

Although complete surgical resection followed by wide-field radiation therapy has been established as a therapeutic standard for AS, delay in diagnosis and older age with comorbidities warrant for a safe and effective adjuvant treatment. Pegylated liposomal doxorubicin combined with radiotherapy seems to be a useful and safe alternative.