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Physical activity and endometrial cancer in a population-based case-control study
Hannah Arem1, Melinda L Irwin, Yang Zhou
1Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06520-8034, USA.
Cancer Causes & Control : CCC
|November 27, 2010
Summary
Engaging in regular moderate- to vigorous-intensity physical activity (MV PA) significantly lowers endometrial cancer risk. Conversely, prolonged sedentary time increases this risk, highlighting the importance of physical activity for women
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Conflicting findings exist regarding the association between physical activity, body mass index (BMI), and endometrial cancer risk.
- Many previous studies lack reporting on the reliability and validity of physical activity assessment tools.
Purpose of the Study:
- To investigate the relationship between moderate- to vigorous-intensity physical activity (MV PA), sedentary time, and endometrial cancer risk.
- To examine the combined effects of physical activity and BMI on endometrial cancer risk.
Main Methods:
- A case-control study involving 667 incident endometrial cancer cases and 662 age-matched controls.
- Utilized interview-administered questionnaires, including a validated tool for assessing physical activity.
- Employed unconditional logistic regression to analyze the associations.
Main Results:
- Women engaging in ≥7.5 MET hours/week of MV PA had a 34% lower risk of endometrial cancer compared to inactive women.
- Sedentary behavior (>8 hours/day sitting) was associated with a 52% increased odds of endometrial cancer.
- A combination of BMI <25 and activity levels ≥7.5 MET hours/week showed a 73% reduced risk compared to overweight and sedentary individuals.
Conclusions:
- Physical activity demonstrates an inverse and independent association with endometrial cancer risk, even after accounting for BMI.
- Findings underscore the protective role of physical activity against endometrial cancer.
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