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Updated: Jun 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Management of castration-resistant prostate cancer: bisphosphonates and emerging therapies

Fred Saad1, Marc Colombel

  • 1Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Canada. fred.saad@umontreal.ca

Expert Review of Anticancer Therapy
|November 30, 2010
PubMed

Insights

Bone metastases are common in prostate cancer, causing pain and skeletal events. Bone-targeted therapies like zoledronic acid and clodronate show promise in managing pain, preventing skeletal events, and improving survival.

Area of Science:

  • Oncology
  • Bone Metastasis Research
  • Prostate Cancer Treatment

Background:

  • Prostate cancer frequently metastasizes to bone, affecting approximately 70% of patients.
  • Bone metastases lead to significant complications, including pain and skeletal-related events.
  • Current treatments aim to palliate pain and manage skeletal complications.

Purpose of the Study:

  • To review the role of bone-targeted therapies in managing prostate cancer bone metastases.
  • To highlight the efficacy of bisphosphonates in reducing skeletal-related events and improving survival.
  • To discuss emerging therapies for maintaining bone health in prostate cancer patients.

Main Methods:

  • Literature review of studies on bisphosphonates and prostate cancer bone metastases.
  • Analysis of clinical trial data on zoledronic acid and clodronate efficacy.
  • Examination of emerging bone-targeted therapies.

Main Results:

  • Zoledronic acid demonstrated significant reduction in skeletal-related events for castration-resistant prostate cancer.
  • Clodronate improved survival in metastatic androgen-sensitive prostate cancer.
  • Bisphosphonates exhibit potential anticancer activity, possibly preventing disease progression.

Conclusions:

  • Bone-targeted therapies are crucial for managing prostate cancer bone metastases.
  • Bisphosphonates offer benefits beyond pain palliation, including improved survival.
  • Continued research into novel bone health therapies is essential for patient outcomes.

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