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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
07:49

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice

Published on: November 14, 2025

Ischemic stroke.

Mara M Kunst1, Pamela W Schaefer

  • 1Section of Neuroradiology, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA. marakunst@gmail.com

Radiologic Clinics of North America
|November 30, 2010
PubMed
Summary
This summary is machine-generated.

This review compares computed tomography and magnetic resonance imaging for acute stroke evaluation. It details imaging protocols and their role in selecting patients for therapies like endovascular treatment to improve outcomes.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Accurate neuroimaging is crucial for optimizing stroke patient outcomes.
  • Tailoring imaging protocols to individual patient needs is essential for effective clinical decision-making.

Purpose of the Study:

  • To review current neuroimaging techniques for acute stroke evaluation.
  • To compare the efficacy of computed tomography (CT) and magnetic resonance imaging (MRI) in assessing brain parenchyma, vasculature, and the ischemic penumbra.
  • To present an institutional imaging algorithm and discuss endovascular therapies for stroke treatment.

Main Methods:

  • Review of routinely used neuroimaging techniques in acute stroke.
  • Comparative analysis of CT and MRI capabilities in stroke assessment.
  • Outline of a specific institutional imaging algorithm.
  • Brief review of endovascular stroke treatment options.

Main Results:

  • CT and MRI have distinct roles in evaluating different aspects of acute stroke.
  • The "ischemic penumbra" can be assessed by advanced imaging techniques.
  • An established imaging algorithm guides patient selection for therapy.

Conclusions:

  • Neuroimaging plays a vital role in patient selection for acute stroke therapies.
  • CT and MRI offer complementary information for comprehensive stroke evaluation.
  • Tailored imaging protocols and algorithms improve patient management and outcomes in acute stroke.