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Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
[Epidemiological and bacteriological characteristics of uropathogen bacteria isolated in a pediatric environment]
A Ferjani1, H Mkaddemi, S Tilouche
1Laboratoire de microbiologie et d'immunologie UR02SP13, CHU Farhat Hached, Sousse, Tunisie. aferjeni@lycos.com
Insights
Pediatric urinary tract infections (UTIs) require prompt care. Escherichia coli is the most common pathogen, showing significant antibiotic resistance, highlighting the importance of urine culture and sensitivity testing for effective treatment.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Context:
- Urinary tract infections (UTIs) are a serious pediatric condition requiring rapid and effective management.
- Bacteriological and epidemiological data are crucial for guiding patient care in pediatric UTIs.
Purpose:
- To analyze the bacteriological and epidemiological characteristics of UTIs in hospitalized children.
- To assess antibiotic resistance patterns of common uropathogens in pediatric patients.
Summary:
- A retrospective study of 51 hospitalized children with UTIs found pyelonephritis to be the predominant diagnosis (94.1%).
- Enterobacteriaceae were the main causative agents, with Escherichia coli isolated in 80.4% of cases.
- High resistance rates of E. coli to amoxicillin (78%) and cotrimoxazole (51%) were observed, while Klebsiella pneumoniae and Proteus mirabilis showed no resistance to third-generation cephalosporins (C3G).
Impact:
- Emphasizes the critical role of cytobacteriological examination of urine (CBEU) for initial diagnosis in pediatric UTIs.
- Highlights the growing challenge of acquired antibiotic resistance in pediatric UTIs, necessitating informed treatment strategies.
- Provides essential data for optimizing antibiotic selection and managing UTIs in children, particularly in the context of evolving resistance patterns.
Abstract:
Urinary tract infection (UTI) in children is a grave pathology, which requires a fast and effective care. Bacteriological and epidemiological data play a determining role in patient's care. We report a retrospective study, which spreads out from January 1st till August 31st, 2009, having concerned hospitalized children for urinary infection in pediatrics service of Farhat Hached teaching hospital in Sousse. Our series contained 51 children with a sex ratio of 0.76, an average age of 32 months. The majority of cases was pyelonephritis (94.1%). A pathology is associated with the urinary infection in 41.2%. Three cases of vesico-ureteral reflux were noted. The diagnosis of urinary infection was confirmed by cytobacteriological exam of urine (CBEU). Enterobacteriacea were isolated in 96.1%. Escherichia coli remains the most often isolated (80.4%), followed by Klebsiella pneumoniae (9.8%) then by Proteus mirabilis (5.9%). E. coli was resistant to amoxicillin in 78% of cases, to the association amoxicillin-clavulanic acid in 64,8%, to cephalosporins of 3(rd) generation (C3G) in 5% and to cotrimoxazole in 51%. No K. pneumoniae or P. mirabilis strain was resistant to C3G. UTI in children is always an indication for CBEU realization at first intention. The results of this exam are very important considering the diversity of the responsible bacteria and the growing frequency of acquired antibiotic resistance.
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