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DNA Helicases00:55

DNA Helicases

DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...

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Related Experiment Video

Updated: Jun 6, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

The RNA helicase database.

Anja Jankowsky1, Ulf-Peter Guenther, Eckhard Jankowsky

  • 1Department of Biochemistry, Center for RNA Molecular Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA.

Nucleic Acids Research
|November 30, 2010
PubMed
Summary

The RNA helicase database offers a centralized resource for comprehensive RNA helicase information. It provides easy access to sequence, structure, and functional data for key model organisms and beyond.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • RNA helicases are vital enzymes involved in numerous RNA metabolism processes.
  • Existing information on RNA helicases is fragmented across various sources.

Purpose of the Study:

  • To create a unified and accessible database for RNA helicase information.
  • To facilitate research by integrating sequence, structure, and functional data.

Main Methods:

  • Data integration from multiple model organisms (E. coli, S. cerevisiae, C. elegans, D. melanogaster, mouse, human).
  • Database structured by the latest helicase classification (superfamilies and families).
  • Implementation of browsing and text-based search functionalities.

Main Results:

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Last Updated: Jun 6, 2026

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  • A comprehensive database (www.rnahelicase.org) is now available.
  • Detailed information on RNA helicases from major model organisms is integrated.
  • Phylogenetic relationships are emphasized through structured classification.

Conclusions:

  • The RNA helicase database serves as a valuable portal for researchers.
  • It simplifies access to diverse RNA helicase data, supporting further investigation.
  • The structured classification aids in understanding evolutionary relationships.