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Updated: Jun 6, 2026
A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
Published on: October 17, 2016
Biocompatibility of tissue engineering constructions from porous polylactide carriers obtained by the method of
T B Bukharova1, E N Antonov, V K Popov
1ReMeTeks Closed Corporation, Moscow, Russia. bukharovarmt@yandex.ru
Abstract:
We studied the biocompatibility of porous polylactide carrier matrices obtained by means of surface selective laser sintering. Carrier matrices had no cytotoxic activity, but maintained adhesion and proliferation of cells. Subcutaneous transplantation of tissue engineering constructions from these carriers and bone marrow-derived multipotent stromal cells did not cause the inflammatory response and pathological changes in rats. The conditions for organotypic regeneration were provided at the site of transplantation (high degree of blood supply and considerable amount of immature precursor cells).
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