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Hepatic and cerebral energy production system in rats with acute and chronic ethanol intoxication

Z V Petrova1, D A Korshunov, V A Slepichev

  • 1Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. zuci@ya.ru

Bulletin of Experimental Biology and Medicine
|November 30, 2010
PubMed

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DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...