Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Measuring the handgrip strength of geriatric patients].

Tijdschrift voor gerontologie en geriatrie·2014

Same author

Tijdschrift voor gerontologie en geriatrie·2012

Same author

Management of patients with mild cognitive impairment and mild to moderate dementia.

Acta clinica Belgica·2009

Same author

Donepezil-related toxic hepatitis.

Acta clinica Belgica·2009

Same author

[A screening tool to identify older people at risk of adverse health outcomes at the time of hospital admission].

Tijdschrift voor gerontologie en geriatrie·2006

Search research articles

Related Experiment Videos

[Nutritional assessment in oncogeriatrics].

M F J Vandewoude¹

¹Hoogleraar Faculteit Geneeskunde Universiteit Antwerpen, Ziekenhuisnetwerk Antwerpen. maurits.vandewoude@ua.ac.be

Tijdschrift Voor Gerontologie En Geriatrie

|December 1, 2010

Summary

Nutritional assessment is crucial for older cancer patients experiencing malnutrition, sarcopenia, and cachexia due to aging and cancer. Early nutritional intervention, integrated into geriatric assessments, can significantly improve outcomes for this vulnerable population.

Area of Science:

Geriatric Medicine
Oncology
Nutritional Science

Context:

Aging involves organ function decline and reduced adaptability, leading to frailty.
Older cancer patients face compounded challenges from aging, poor dietary intake, and tumor-induced inflammation.
This creates a significant overlap between starvation, sarcopenia, and cachexia in this demographic.

Purpose:

To emphasize the necessity of routine nutritional assessment in older oncology patients.
To differentiate between nutritional risk assessment and the evaluation of actual nutritional status using specific indices.
To highlight the importance of comprehensive geriatric assessment for framing nutritional interventions.

Summary:

Nutritional assessment, including body weight and unintended weight loss evaluation, is essential for older cancer patients.

Related Experiment Videos

While Body Mass Index (BMI) requires cautious interpretation, low values indicate increased malnutrition risk.

Early identification of nutritional issues facilitates timely intervention.

Impact:

Increased awareness of nutritional problems in older cancer patients promotes early and effective intervention strategies.
Integrating nutritional assessment within comprehensive geriatric assessments ensures a holistic approach to patient care.
Proactive nutritional management can mitigate the adverse effects of malnutrition, sarcopenia, and cachexia, potentially improving patient outcomes.