[The Clinical Applicability of Blood Biomarkers for Alzheimer's disease in the Memory Clinic]
Marleen Kloppenburg-Lagendijk1, Yinkje Huitema2, Argonde van Harten3,4
1Afdeling Geriatrie, Geheugenpolikliniek, Frisius Medisch Centrum, locatie Leeuwarden.
Background:
The development of highly sensitive assays has enabled the detection of biomarkers of Alzheimer's disease in blood. In this literature review, we discuss their clinical applicability based on recent studies.
Methods:
A systematic search was conducted across Embase, Pubmed, Web of Science, Cochrane Central, and Google Scholar for studies published since 2021, using the search terms 'Alzheimer's Disease', 'Blood Biomarkers' and 'Memory Clinic'.
Results:
Based on the 11 included studies, pTau181, pTau217, NfL and GFAP appear to be clinically relevant (diagnostic value, AUC > 0.7) as blood biomarker.
Conclusions:
Multiple blood biomarkers appear to be clinically relevant for diagnostics in a memory clinic setting. However, this conclusion is based on just 11 studies, highlighting the need for further research in real-world populations within memory clinics.
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