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Related Experiment Video

Updated: Jun 6, 2026

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder

Published on: June 6, 2025

Antibacterial iodine-supported titanium implants.

T Shirai¹, T Shimizu, K Ohtani

¹Department of Orthopaedic Surgery, Kanazawa University, Takaramachi, Kanazawa, Japan.

Acta Biomaterialia

|December 1, 2010

Summary

Iodine-supported titanium (Ti-I(2)) shows significant antibacterial activity, reducing implant-associated infections. This promising biomaterial is cytocompatible and supports bone formation, making it suitable for orthopedic surgery.

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Area of Science:

Biomaterials Science
Orthopedic Surgery
Infectious Diseases

Background:

Deep infections are a major risk in orthopedic implant surgery.
Biomaterial surface treatments are crucial for preventing implant-associated infections.
Iodine-supported titanium (Ti-I(2)) is explored as a novel antimicrobial biomaterial.

Purpose of the Study:

To evaluate the antibacterial activity of Ti-I(2).
To assess the impact of Ti-I(2) on post-implant infection.
To determine the suitability of Ti-I(2) as an orthopedic biomaterial.

Main Methods:

Antibacterial activity tested using a modified Japanese Industrial Standards method with Staphylococcus aureus and Escherichia coli.
Cytocompatibility assessed via fibroblast colony formation.
In vivo study in rabbits using external fixation pins for infection, inflammation, and osteoconductivity evaluation.

Main Results:

Ti-I(2) significantly inhibited bacterial colonization compared to stainless steel and titanium controls.
Fibroblast colony formation was similar across Ti-I(2), titanium, and stainless steel.
In vivo studies showed reduced infection and inflammation with Ti-I(2) pins, alongside enhanced bone formation.

Conclusions:

Ti-I(2) possesses significant antimicrobial properties and is cytocompatible.
Ti-I(2) effectively reduces implant-associated infections.
Ti-I(2) demonstrates promise as a biomaterial for orthopedic implants due to its antimicrobial and osteoconductive potential.