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Updated: Jun 6, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel polyazaheterocyclic systems: Synthesis, antitumor, and antimicrobial activities
Sayed M Riyadh1, Thoraya A Farghaly, Sobhi M Gomha
1Department of Chemistry, University of Cairo, Giza, Egypt.
Abstract:
A series of new polyazaheterocyclic ring systems was synthesized via the reaction of enaminone 5 with active methylene compounds, hydrazine hydrate, hydroxylamine, and heterocyclic amines. The structures of the newly synthesized compounds were substantiated on the basis of spectral data and elemental analyses. The antitumor activity of the enaminone 5 against the human breast cell line MCF-7, the liver carcinoma cell line HEPG2-1, and HELA cells was determined. In addition, the antimicrobial activity of some selected products was evaluated.
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