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Updated: Jun 6, 2026

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
Published on: November 11, 2014
HSP70 and lysosomal storage disorders: novel therapeutic opportunities
Nikolaj H T Petersen1, Thomas Kirkegaard
1Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Abstract:
Lysosomes, with their arsenal of catabolic enzymes and crucial metabolic housekeeping functions are experiencing a revived research interest after having lived a rather quiet life for the last few decades. With the discovery of the interaction of the lysosomes with another ancient component of cellular homoeostasis, the molecular chaperone HSP70 (heat-shock protein 70), the stage seems set for further discoveries of the mechanisms regulating cellular and physiological stress responses to otherwise detrimental challenges.
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