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Related Experiment Video

Updated: Jun 6, 2026

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
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Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

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Animal models for neural diseases.

Gary W Jay1, Ronald B Demattos, Edward J Weinstein

  • 1Pfizer Global Research, Groton, CT 06340, USA. Thomas.P.Brown@pfizer.com

Toxicologic Pathology
|December 2, 2010
PubMed
Summary

Choosing appropriate animal models is crucial for studying neurological diseases and developing treatments. New technologies offer improved models, aiding translational medicine for better public health outcomes.

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Area of Science:

  • Toxicologic Pathology
  • Neuropathology
  • Translational Medicine

Background:

  • General Session 5 at a 2010 symposium focused on animal models of neural disease.
  • The Society of Toxicologic Pathology (STP) and International Federation of Societies of Toxicologic Pathologists (IFSTP) co-sponsored the event.
  • Discussions centered on selecting suitable animal models for investigating neurological diseases and therapeutics.

Purpose of the Study:

  • To address challenges in selecting appropriate animal models for neuropathology research.
  • To explore the utility of existing and emerging technologies for creating new models.
  • To ensure animal model data effectively supports translational medicine.

Main Methods:

  • Review of current challenges in animal model selection for neurological diseases.

Related Experiment Videos

Last Updated: Jun 6, 2026

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

  • Discussion of specific examples like fibromyalgia syndrome and Alzheimer's disease.
  • Consideration of novel technologies such as genetically engineered rodent models and in vitro models.

    • Main Results:

    • No universal animal model exists for all human neurological diseases.
    • Selection of the most appropriate model is critical when multiple options are available.
    • Emerging technologies like genetic engineering and in vitro systems present new avenues for model development.

    Conclusions:

    • The complexity of neurological diseases necessitates ongoing evaluation of animal models.
    • Advanced technologies can help bridge the gap for diseases lacking adequate models.
    • Optimizing animal model selection and development is essential for advancing translational medicine and public health.