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Related Experiment Video

Updated: Jan 10, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

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Hot Topics, Future Directions, and Challenges Faced in Toxicologic Neuropathology.

Alys E Bradley¹, Elizabeth Galbreath², Felix Goulet³

¹Charles River Laboratories Edinburgh, Tranent, UK.

Toxicologic Pathology

|November 28, 2025

Summary

This summary is machine-generated.

This session explored key issues in toxicologic neuropathology, including brain drug delivery, dorsal root ganglia collection, and digital pathology advancements for nervous system assessment.

Keywords:

DRG digital intracisternal intraparenchymal

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Area of Science:

Toxicologic Neuropathology
Neuroscience
Digital Pathology

Background:

The Society of Toxicologic Pathology Annual meeting featured a session on critical aspects of toxicologic neuropathology.
Discussions centered on current challenges and future directions in the field.

Purpose of the Study:

To address emerging topics and challenges in toxicologic neuropathology.
To explore innovative techniques and methodologies for nervous system assessment.

Main Methods:

Panel discussions on direct brain agent delivery.
Addressing challenges in cervical dorsal root ganglia collection.
Exploring novel digital pathology techniques for nervous system evaluation.

Main Results:

Identified key challenges in direct brain delivery of agents.
Highlighted difficulties and potential solutions for dorsal root ganglia sampling.
Showcased advancements in digital pathology for neuro-assessment.

Conclusions:

Toxicologic neuropathology faces evolving challenges requiring innovative solutions.
Direct brain delivery, ganglia collection, and digital pathology are crucial areas for future research and development.