Related Experiment Video
Updated: Apr 10, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
Carcinogenicity in the 21st Century: Data Interpretation-Session 4
Sandra De Jonghe1, Matthew Jacobsen2, Jim Saul3
1Johnson & Johnson Innovative Medicine, Beerse, Belgium.
None:
The 2025 joint British Society of Toxicologic Pathology (BSTP) and European Society of Toxicologic Pathology (ESTP) Congress included a session on data interpretation, which can be complex and is a critical aspect of carcinogenicity studies. In addition to statistical analysis, consistency in nomenclature, high-quality peer review, the appropriate use of historical control data, knowledge on compound- and target-related information, and literature can contribute to high-quality data, optimal interpretation of biological relevance, and safety assessment. The speakers covered several of these aspects which are critical in data interpretation of carcinogenicity studies. Based on experience and case examples, recommendations for updating International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) terminology for some proliferative findings in exocrine pancreas, liver, and ovaries were presented, including a case example of human relevance and risk assessment of endocrine and reproductive system tumors.
More Related Videos
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
04:12Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Related Concept Videos
Mutagenicity and Carcinogenicity
Toxicity Testing in Animals
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer Survival Analysis
Cancer Prevention
Some...
Teratogenicity