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Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel

Zhi-Quan Huang1, Wei-liang Chen, Hai-Gang Li

  • 1Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China.

The Journal of Craniofacial Surgery
|December 2, 2010
PubMed

Insights

Extracellular matrix metalloproteinase inducer (EMMPRIN) is elevated in malignant salivary gland tumors and correlates with increased microvessel density (MVD). EMMPRIN may serve as a biomarker for tumor characterization and indicates angiogenic potential.

Area of Science:

  • Oncology
  • Pathology
  • Biochemistry

Background:

  • Salivary gland tumors exhibit diverse histopathological features.
  • Understanding the molecular drivers of tumor progression is crucial for diagnosis and treatment.
  • Extracellular matrix metalloproteinase inducer (EMMPRIN) is implicated in tumor growth and angiogenesis.

Purpose of the Study:

  • To investigate the expression patterns of EMMPRIN in various salivary gland tumors.
  • To determine the correlation between EMMPRIN expression and microvessel density (MVD).
  • To evaluate EMMPRIN as a potential biomarker for salivary gland tumors.

Main Methods:

  • Immunohistochemistry was used to assess EMMPRIN expression and MVD in 95 paraffin-embedded salivary gland tumor specimens.
  • Reverse transcription-polymerase chain reaction (RT-PCR) was employed to analyze EMMPRIN mRNA levels in frozen samples.
  • Statistical analysis was performed to compare expression levels and MVD between different tumor types and groups.

Main Results:

  • EMMPRIN expression and MVD were significantly higher in mucoepidermoid carcinomas and adenoid cystic carcinomas compared to normal tissues and pleomorphic adenomas (P < 0.05).
  • MVD was significantly elevated in EMMPRIN-positive tumors compared to EMMPRIN-negative tumors (P < 0.05).
  • EMMPRIN mRNA levels were higher in malignant salivary gland tumors than in pleomorphic adenomas (P < 0.05).

Conclusions:

  • EMMPRIN expression is a significant characteristic of malignant salivary gland tumors.
  • EMMPRIN can serve as a valuable biologic marker for classifying salivary gland tumors.
  • EMMPRIN acts as a positive angiogenic factor in the tumor microenvironment of salivary gland tumors.

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