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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

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Self-mutilation and pharmacotherapy.

Brian Daniel Smith¹

¹Dr. Smith is from the Department of Psychiatry, Michigan State University, East Lansing, Michigan.

Psychiatry (Edgmont (Pa. : Township))

|December 2, 2010

Summary

This summary is machine-generated.

Limited evidence suggests pharmacotherapy can help reduce self-mutilation. Further research, particularly double-blind, placebo-controlled trials, is needed to confirm the effectiveness of treatments like SSRIs and mood stabilizers.

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Area of Science:

Psychiatry
Pharmacology
Clinical Psychology

Background:

Self-mutilation is a complex behavior often associated with personality disorders.
Understanding effective pharmacologic interventions for self-mutilation is crucial for patient care.

Purpose of the Study:

To critically review existing clinical reports on the pharmacotherapy of self-mutilation.
To synthesize evidence supporting the use of various medications in managing self-harm behaviors.

Main Methods:

Comprehensive literature search of PubMed from 1950 onwards.
Focused review on pharmacotherapy for self-mutilation, deliberate self-harm, and borderline personality disorder.

Main Results:

Open studies and case reports indicate potential benefits of SSRIs, naltrexone, atypical antipsychotics, mood stabilizers, and clonidine.
More robust studies show general reductions in impulsive aggression with antidepressants, antipsychotics, and mood stabilizers, particularly in borderline personality disorder.

Conclusions:

Preliminary evidence supports the pharmacologic management of self-mutilation.
High-quality, double-blind, placebo-controlled trials are necessary to validate these findings and guide clinical practice.