Related Experiment Video
Updated: Jun 6, 2026

08:25
Flow Cytometric Characterization of Murine B Cell Development
Published on: January 22, 2021
Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency
Mirjam van der Burg1, Menno C van Zelm, Gertjan J A Driessen
1Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. m.vanderburg@erasmusmc.nl
Advances in Experimental Medicine and Biology
|December 2, 2010
Abstract
No abstract available in PubMed .
Related Concept Videos
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

