Related Experiment Video
Updated: Jun 6, 2026

A Murine Tail Lymphedema Model
Published on: February 10, 2021
Anatomical and Surgical Concepts in Lymphatic Regeneration
Tomer Avraham1, Sanjay V Daluvoy, Essie Kueberuwa
1The Division of Plastic and Reconstructive Surgery, The Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, New York 10065, USA. mehrarab@mskcc.org
Abstract:
Chronic post-surgical lymphedema is common condition that afflicts nearly 2 million Americans. In the USA, it is most commonly encountered in the upper extremities of patients who have undergone axillary lymph node dissection for breast cancer. Lymphedema has a significant negative effect on cosmesis, limb function, and overall quality of life. Despite the impact of this condition, very little is known about how to effectively prevent or treat lymphedema. While therapeutic options for chronic extremity lymphedema remain limited, several surgical approaches have been suggested. These include techniques aimed at reducing limb volume, as well as techniques that aim to reconstitute disrupted lymphatic channels. Operations proposed to re-establish lymphatic continuity include lymphatico-venous anastomoses, lymphatico-lymphatico anastomoses, and tissue transfer.
Related Concept Videos
Development of the Lymphatic System
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphatic Vessels and Lymph Transport
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Detailed Structure and Function of Lymph Nodes
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Introduction to Lymphatic and Immune System
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...