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Updated: Jun 6, 2026

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
Published on: May 12, 2023
[Pharmacogenetics in cardiovascular diseases therapy--treatment according guidelines or according the individual
1Univerzita Karlova V Praze, 3, lékarská fakulta, Ustav farmakologie, Praha. jbult@lf1.cuni.cz
Abstract:
In clinical practice the individual response to a drug represents a great problem. Many of us experienced a situation when the drug effect declined or drug-related toxic reaction occurred. The typical example is the variation of optimal warfarin dosage. The main cause of interindividual differences in the drug response is the polymorphism in drug resorption and elimination systems, enzymes responsible for drug biotransformation, target receptors or signal molecules. The individualized drug therapy requires physicians to be oriented in main causes of pharmacokinetic and pharmacodynamic variations and be able to predict accurately the individual drug response.
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