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The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic
Semaan Kosseifi1, Beth Bailey, Robert Price
1Division of Pulmonary and Critical Care, Department of Internal Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
Background:
Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance.
Objective:
We studied the link between sleep apnea and microvascular diabetic complications in veterans with type 2 diabetes mellitus (DM-2).
Design:
A retrospective electronic chart of all veterans referred for sleep studies over a 1-year period was reviewed. Ninety-eight patients with a glycosylated hemoglobin < 6.5% were included in the study. The degree of glycemia (HbA1c) and presence of macro- and microvascular complications were compared with OSAS variables.
Method:
Statistical analysis examined bivariate associations between OSAS variables and metabolic syndrome parameters.
Results:
The apnea hypopnea index was significantly related to diabetic microvascular complications, particularly retinopathy. Oxygen desaturation was significantly and inversely related to microalbuminuria, microvascular complications, retinopathy, and HbA1c.
Conclusions:
Sleep apnea is associated with microvascular complications even in well-controlled DM-2 veterans.
Clinical Implications:
Screening for OSAS should be considered in patients with DM-2.
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