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Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Platelet function testing: methods of assessment and clinical utility.

Darren Mylotte1, David Foley, Dermot Kenny

  • 1Department of Cardiology, Beaumont Hospital, Dublin, Ireland. darrenmylotte@rcsi.ie

Cardiovascular & Hematological Agents in Medicinal Chemistry
|December 3, 2010
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Summary

Platelet function tests, once for bleeding disorders, now aid cardiovascular disease management. Measuring response to antiplatelet drugs like aspirin predicts clinical events, showing their growing importance.

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Last Updated: Jun 6, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Published on: May 2, 2025

Microfluidics in Assessing Platelet Function
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Hematology
  • Cardiovascular Medicine
  • Clinical Diagnostics

Background:

  • Platelets are crucial for thrombosis and hemostasis.
  • Platelet function tests were traditionally used for bleeding disorders.
  • Recent research highlights their utility in cardiovascular disease.

Purpose of the Study:

  • To review current methods for measuring platelet function.
  • To discuss the advantages and disadvantages of these tests.
  • To explore the clinical utility and emerging data for platelet function studies.

Main Methods:

  • Ex vivo measurement of platelet response to antiplatelet therapies (aspirin, clopidogrel).
  • Analysis of an increasing array of platelet function tests.
  • Review of existing literature and clinical data.

Main Results:

  • Some platelet function assays predict adverse clinical events in patients on antiplatelet therapy.
  • Platelet function testing is an emerging area of clinical and scientific interest.
  • Data supports the role of these studies in clinical practice.

Conclusions:

  • Platelet function testing has expanded beyond bleeding disorders into cardiovascular disease management.
  • Specific assays can predict patient outcomes on antiplatelet medications.
  • Further research and clinical application of these tests are warranted.