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Ovulation rate in adolescents with type 1 diabetes mellitus
Ethel Codner1, Francisca C Eyzaguirre, Germán Iñiguez
1Institute of Maternal and Child Research, School of Medicine, University of Chile, San Borja Arriarán Hospital, Santiago, Chile. ecodner@med.uchile.cl
Objective:
To study ovulation in adolescents with type 1 diabetes (T1D) and the effect of hemoglobin A1c (HbA1c) levels on their ovulatory function.
Design:
Prospective investigation.
Setting:
Academic research institute.
Patient(S):
Adolescents with T1D (n=31) and healthy girls (n=52).
Intervention(S):
Ovulation assessed through the measurement of salivary progesterone (days 13, 18, 23, and 28 of each cycle).
Main Outcome Measure(S):
Proportion of ovulatory cycles.
Result(S):
A total of 168 and 281 menstrual cycles were studied in the T1D and control girls, respectively. Metabolic control was defined as optimal if HbA1c was <7.5%. The proportion of ovulatory cycles was similar in the TID and control groups (34.5% and 36.3%, respectively). Regression analyses showed that the presence of T1D did not have a statistically significant effect on the ovulatory rate. However, more ovulatory cycles were observed in girls with T1D who had optimal metabolic control compared with those who had insufficient control (51.3% vs. 29.4%).
Conclusion(S):
In adolescent girls, T1D did not affect the rate of ovulation. A higher ovulatory rate was observed in those with optimal control compared with those with insufficient metabolic control, but a substantial proportion of ovulatory cycles were still observed in patients with higher HbA1c levels.
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