Related Experiment Video
Updated: Jun 6, 2026
Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
Conservation of salivary function and new external head and neck radiation techniques
J Thariat1, N Guevara, P-Y Marcy
1IBDC CNRS UMR 6543, département de radiothérapie oncologie, centre Antoine-Lacassagne, université Nice-Sophia-Antipolis, 33, avenue Valombrose, 06189 Nice cedex 2, France. jthariat@hotmail.com
Introduction:
New radiation therapy techniques seek to adapt dose distribution to three-dimensional tumor geometry, so as to deliver the lowest possible dose to normal tissue and at-risk organs. This is expected to enhance locoregional control and survival and to reduce complications and thereby improve quality of life. Post-radiation xerostomia significantly deteriorates quality of life.
Material And Methods:
New external radiation techniques (such as intensity-modulated conformal radiation therapy, RapidArc VMAT arc therapy, tomotherapy, CyberKnife(®), protontherapy, use of carbon ions) applicable in ENT are reviewed.
Results:
Preliminary data show interesting results in terms of salivary function with highly conformal techniques.
Conclusion:
In France, assessment is ongoing, financed under the Health Ministry's "Support for Expensive Innovatory Techniques" scheme (STIC [Soutien aux techniques innovantes coûteuses]), as routine use is growing rapidly.
